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Buy Avalide online and save up to 80% on costs. No US insurance needed. Compare prices from a certified Canadian pharmacy with fast shipping. Order now. Avalide is a combination medication containing irbesartan and hydrochlorothiazide. It's used to treat high blood pressure (hypertension). Irbesartan is an angiotensin receptor blocker (ARB) that relaxes blood vessels to lower blood pressure. Hydrochlorothiazide is a diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. AVALIDE prescription and dosage information for physicians and health care professionals. Pharmacology, adverse reactions, warnings, and AVALIDEside effects. What Is Avalide? Avalide (irbesartan w/ hydrochlorothiazide) is a combination of an angiotensin II receptor blocker and a thiazide diuretic (water pill) prescribed for the treatment of high blood pressure. What Are Side Effects of Avalide? 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