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Xyzal (levocetirizine) is a fast-acting allergy relief medication that lasts for up to 24 hours and is safe for adults and children. Learn about dosing Xyzal here. Xyzal allergy tablets are an effective antihistamine with active ingredient levocetirizine dihydrochloride that starts working in 45 minutes and provides 24-hour relief of allergy symptoms including sneezing; itchy, watery eyes; runny nose; itchy nose or throat. Xyzal is a histamine H1-receptor antagonist used for the relief of symptoms associated with seasonal and perennial allergic rhinitis, and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria. Book a video visit with a Sesame provider and get a levocetirizine (Xyzal) prescription online if appropriate. Levocetirizine is an antihistamine that treats allergy symptoms and chronic hives. Most people feel better in a few hours. 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