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Find patient medical information for Glyburide/Metformin (Glucovance) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Glucovance (Glyburide and Metformin) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Helping patients to take control of their blood glucose levels, by delivering the benefits of two components in one pill. The dosage of Glucovance ® should be adjusted depending on renal function parameters (start with 1 tablet of Glucovance ® 500 mg/2.5 mg); regular checks on the renal function are necessary. Patients aged 65 years and older: Starting and maintenance doses of glibenclamide must be carefully adjusted to reduce the risk of hypoglycemia. Glucovance combines glyburide and metformin hydrochloride to help manage blood sugar levels in adults with type 2 diabetes. 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